Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin
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چکیده
منابع مشابه
Neutrophil elastase-induced elastin degradation mediates macrophage
23 Neutrophil (PMNL) influx precedes lung macrophage (LM) influx into the lung following 24 exposure of newborn pups to 60% O2. We hypothesized that PMNL were responsible for the 25 signals leading to LM influx. This was confirmed when inhibition of PMNL influx with a CXC 26 chemokine receptor-2 antagonist, SB-265610, also prevented the 60% O2-dependent LM influx, 27 LM-derived nitrotyrosine fo...
متن کاملCrystallization of human neutrophil elastase.
Human neutrophil elastase was inactivated by methoxysuccinyl-L-Ala-L-Ala-L-Pro-L-Ala-chloromethane. The modified enzyme was crystallized from 40 mM ammonium phosphate, pH 7.0 in the hexagonal space group P6(3) with unit cell parameters a = 74.53 A, b = 74.53 A, c = 70.88 A, alpha = beta = 90 degrees, gamma = 120 degrees. These crystals were resistant to radiation damage and diffracted beyond 1....
متن کاملthe effect of vocabulary instruction through semantic mapping on learning and recall of efl learners
چکیده ندارد.
15 صفحه اولPrimary structure of human neutrophil elastase.
The complete amino acid sequence of human neutrophil elastase has been determined. The protein consists of 218 amino acid residues, contains two asparagine-linked carbohydrate side chains, and is joined together by four disulfide bonds. Comparison of the sequence to other serine proteinases indicates only moderate homology with porcine pancreatic elastase (43.0%) or neutrophil cathepsin G (37.2...
متن کاملStructure of the human neutrophil elastase gene.
The gene for human neutrophil elastase (NE), a powerful serine protease carried by blood neutrophils and capable of destroying most connective tissue proteins, was cloned from a genomic DNA library of a normal individual. The NE gene consists of 5 exons and 4 introns included in a single copy 4-kilobase segment of chromosome 11 at q14. The coding exons of the NE gene predict a primary translati...
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ژورنال
عنوان ژورنال: Journal of Trauma and Acute Care Surgery
سال: 2017
ISSN: 2163-0763,2163-0755
DOI: 10.1097/ta.0000000000001685